APACERAM / APACERAM-AX

Hydroxyapatite [Ca10(PO4)6(OH)2] has excellent biocompatibility and biological safety, and is available in a wide variety of APACERAM and ultra-high porosity APACERAM-AX with a porosity of 85% with a triple pore structure.

APACERAM

Biocompatible ceramic bone graft substitute APACERAM was created by our own unique technology.

Approved products, models and indications may differ from country to country.
Please contact us for detail.

APACERAM-AX

APACERAM-AX is a bone replacement material with a characteristic microstructure originally developed by our company, and means “new axial attachment (AXIS), highest (MAX) porosity, and highest (MAX) osteogenic capacity” in the APACERAM product group.

Features of APACERAM

Biocompatibility

APACERAM consists of synthetic hydroxyapatite 〔Ca10(PO4)6(OH)2〕that is an inorganic component of human bone. It has excellent biocompatibility and biological safety.

Osteoconductivity

APACERAM has macro pores and micro pores in the structure. Macro pores are effective for new bone formation, while micro pores provide interconnectivity of the pores.

Wide variation

Wide varieties of the models are available with various mechanical strength and porosity depending on the application sites and intended use.

Feature of APACERAM porous materials

SEM image of porous surface (porosity 50%): Continuous porosity

Undecalcified sample of APACERAM that has been placed in the femur of adult canine (3 months after implantation).New bone was observed intruding into pores of APACERAM.

Feature of APACERAM (dense material)

SEM image of the dense material (surface)
High density sintered body consisting of closely packed particles of 0.3～0.5μm.

TEM image of the interface between APACERAM (dense material) and the bone【Photo】 Dr. Makoto Ogiso (Tokyo Medical Dental University) Crystalline particles are continuously emerging in the same direction at the interface between bone and APACERAM. It confirms complete chemical bonding between bone and APACERAM. (TEM image：2 months after implantation)

Porosity and strength

Porosity (%)	3-point flexural strength MPacompressive	strength MPa
0	220	730
5	90	540
15	50	240
30	27	175
40	16	65
50	10	30
55	9	20
60	7	15

Product Line-up (APACERAM)

A variety of porosity and shapes are available depending on the intended use and implantation site, including versatile blocks, granules and various spacers.

*Please refer to the catalog for details. (Please refer to the product catalog page)

Features of APACERAM-AX

Triple pore structure

This is an ultra-high-porosity hydroxyapatite artificial bone with 85% porosity and a triple-pore structure:① Spherical macro pores, ② Considerable interconnecting pores, ③ micro pores among the spherical particles

Assimilation with bone tissue*

It bonds with the surrounding bone as new bone grows inside its pores.

Implanted in the defect Ø4mm × 6mmL in the iliac of the beagle (radiography).

In 26th weeks after implantation, boundaries around the material became vague showing progress of new bone formation.
* To become almost same situation as bone tissue in terms of structures and functions.

Early osteogenic ability

Interconnecting pore structure and porous inner wall structure of the pores enable early bone formation.
a) Implanted in the defect Ø4mm × 6mmL in the iliac of the beagle (Toluidine blue staining).

In 4 weeks after implantation, new bone formation was observed all over the implanted site with active new bone in the pores.

b) Implantation of APACERAM-AX in the defect Ø4mm × 12mmL in the iliac of the beagle. (Hematoxylin Eosin staining)

In 4 weeks after implantation, new bone formation was observed in the pores and osteoblasts were found on the surface of the newly formed bone.

Product Line-up (APACERAM-AX)

Product number	name	classification, name, abbreviated	packaging unit/box
GA-2	Granules 1.0-2.0mm	Artificial Bone, AB-01	2g
GA-3	Filler 3.0±1.0mm	Artificial Bone AB-01	2g
A-1	block 10×10×10mm	artificial bone, AB-02	1ml×1 Piece
A-2	block 10×10×20mm	artificial bone, AB-02	2ml×1 Piece
A-3	PLF Stick 4×4×40mm	Artificial Bone / AB-13	1