{"id":2984,"date":"2024-09-05T16:11:03","date_gmt":"2024-09-05T07:11:03","guid":{"rendered":"https:\/\/hoyats.cr8ive.fun\/products\/product_details\/apaseram-apaseram-ax\/"},"modified":"2026-02-27T10:12:17","modified_gmt":"2026-02-27T01:12:17","slug":"apaseram-apaseram-ax","status":"publish","type":"medical_products","link":"https:\/\/www.hoyatechnosurgical.co.jp\/en\/products\/product_details\/apaseram-apaseram-ax\/","title":{"rendered":"APACERAM \/ APACERAM-AX"},"content":{"rendered":"\n<h2 class=\"wp-block-heading\">APACERAM \/ APACERAM-AX<\/h2>\n\n\n\n<p>Hydroxyapatite [Ca10(PO4)6(OH)2] has excellent biocompatibility and biological safety, and is available in a wide variety of APACERAM and ultra-high porosity APACERAM-AX with a porosity of 85% with a triple pore structure.<\/p>\n\n\n\n<h3 class=\"wp-block-heading\">APACERAM<\/h3>\n\n\n\n<p>Biocompatible ceramic bone graft substitute APACERAM was created by our own unique technology.<\/p>\n\n\n\n<p>Approved products, models and indications may differ from country to country.<br>Please contact us for detail.<\/p>\n\n\n\n<h3 class=\"wp-block-heading\">APACERAM-AX<\/h3>\n\n\n\n<p>APACERAM-AX is a bone replacement material with a characteristic microstructure originally developed by our company, and means &#8220;new axial attachment (AXIS), highest (MAX) porosity, and highest (MAX) osteogenic capacity&#8221; in the APACERAM product group.<\/p>\n\n\n\n<h2 class=\"wp-block-heading\">Features of APACERAM<\/h2>\n\n\n\n<h4 class=\"wp-block-heading\">Biocompatibility<\/h4>\n\n\n\n<p>APACERAM consists of synthetic hydroxyapatite \u3014Ca10(PO4)6(OH)2\u3015that is an inorganic component of human bone. It has excellent biocompatibility and biological safety.<\/p>\n\n\n\n<h4 class=\"wp-block-heading\">Osteoconductivity<\/h4>\n\n\n\n<p>APACERAM has macro pores and micro pores in the structure. Macro pores are effective for new bone formation, while micro pores provide interconnectivity of the pores.<\/p>\n\n\n\n<h4 class=\"wp-block-heading\">Wide variation<\/h4>\n\n\n\n<p>Wide varieties of the models are available with various mechanical strength and porosity depending on the application sites and intended use.<\/p>\n\n\n\n<h3 class=\"wp-block-heading\">Feature of APACERAM porous materials<\/h3>\n\n\n\n<h6 class=\"wp-block-heading has-text-align-center\">SEM image of porous surface (porosity 50%): Continuous porosity<\/h6>\n\n\n<div class=\"wp-block-image\">\n<figure class=\"aligncenter size-full is-resized\"><img loading=\"lazy\" decoding=\"async\" width=\"876\" height=\"362\" src=\"https:\/\/www.hoyatechnosurgical.co.jp\/wp\/wp-content\/uploads\/2024\/09\/apaseram_photo1-1.png\" alt=\"\" class=\"wp-image-4952\" style=\"width:406px;height:auto\" srcset=\"https:\/\/www.hoyatechnosurgical.co.jp\/wp\/wp-content\/uploads\/2024\/09\/apaseram_photo1-1.png 876w, https:\/\/www.hoyatechnosurgical.co.jp\/wp\/wp-content\/uploads\/2024\/09\/apaseram_photo1-1-768x317.png 768w\" sizes=\"auto, (max-width: 876px) 100vw, 876px\" \/><\/figure>\n<\/div>\n\n\n<h6 class=\"wp-block-heading has-text-align-center\">Undecalcified sample of APACERAM that has been placed in the femur of adult canine (3 months after implantation).New bone was observed intruding into pores of APACERAM.<\/h6>\n\n\n<div class=\"wp-block-image\">\n<figure class=\"aligncenter size-full is-resized\"><img loading=\"lazy\" decoding=\"async\" width=\"237\" height=\"152\" src=\"https:\/\/www.hoyatechnosurgical.co.jp\/wp\/wp-content\/uploads\/2024\/09\/apaseram_photo3.jpg\" alt=\"\" class=\"wp-image-4946\" style=\"width:255px;height:auto\"\/><\/figure>\n<\/div>\n\n\n<h3 class=\"wp-block-heading\">Feature of APACERAM (dense material)<\/h3>\n\n\n\n<h6 class=\"wp-block-heading has-text-align-center\"><strong>SEM image of the dense material (surface<\/strong>)<br>High density sintered body consisting of closely packed particles of 0.3\uff5e0.5\u03bcm.<\/h6>\n\n\n<div class=\"wp-block-image\">\n<figure class=\"aligncenter size-full is-resized\"><img loading=\"lazy\" decoding=\"async\" width=\"183\" height=\"118\" src=\"https:\/\/www.hoyatechnosurgical.co.jp\/wp\/wp-content\/uploads\/2024\/09\/photo4.jpg\" alt=\"\" class=\"wp-image-4963\" style=\"width:255px;height:auto\"\/><\/figure>\n<\/div>\n\n\n<h6 class=\"wp-block-heading has-text-align-center\">TEM image of the interface between APACERAM (dense material) and the bone<span style=\"color: rgb(51, 51, 51); font-family: Arial, Helvetica, sans-serif; font-size: 14px; font-weight: 400; letter-spacing: normal; text-align: start; white-space-collapse: collapse;\"><\/span>\u3010Photo\u3011 Dr. Makoto Ogiso (Tokyo Medical Dental University)  Crystalline particles are continuously emerging in the same direction at the interface between bone and APACERAM. It confirms complete chemical bonding between bone and APACERAM. (TEM image\uff1a2 months after implantation)<\/h6>\n\n\n<div class=\"wp-block-image\">\n<figure class=\"aligncenter size-full is-resized\"><img loading=\"lazy\" decoding=\"async\" width=\"183\" height=\"118\" src=\"https:\/\/www.hoyatechnosurgical.co.jp\/wp\/wp-content\/uploads\/2024\/09\/photo5.jpg\" alt=\"\" class=\"wp-image-4966\" style=\"width:255px;height:auto\"\/><\/figure>\n<\/div>\n\n\n<h3 class=\"wp-block-heading\">Porosity and strength<\/h3>\n\n\n\n<figure class=\"wp-block-flexible-table-block-table is-content-justification-center\"><table class=\"has-fixed-layout\" style=\"width:65%\"><tbody><tr><td style=\"background-color:#2c66b0;color:#ffffff;text-align:center;vertical-align:middle\">Porosity (%)<\/td><td style=\"background-color:#2c66b0;color:#ffffff;text-align:center;vertical-align:middle\">3-point flexural strength MPacompressive<\/td><td style=\"background-color:#2c66b0;color:#ffffff;vertical-align:middle;text-align:center\">strength MPa<\/td><\/tr><tr><td style=\"text-align:center;vertical-align:middle\">0<\/td><td style=\"text-align:center;vertical-align:middle\">220<\/td><td style=\"text-align:center;vertical-align:middle\">730<\/td><\/tr><tr><td style=\"text-align:center;vertical-align:middle\">5<\/td><td style=\"text-align:center;vertical-align:middle\">90<\/td><td style=\"text-align:center;vertical-align:middle\">540<\/td><\/tr><tr><td style=\"text-align:center;vertical-align:middle\">15<\/td><td style=\"text-align:center;vertical-align:middle\">50<\/td><td style=\"text-align:center;vertical-align:middle\">240<\/td><\/tr><tr><td style=\"text-align:center;vertical-align:middle\">30<\/td><td style=\"text-align:center;vertical-align:middle\">27<\/td><td style=\"text-align:center;vertical-align:middle\">175<\/td><\/tr><tr><td style=\"text-align:center;vertical-align:middle\">40<\/td><td style=\"text-align:center;vertical-align:middle\">16<\/td><td style=\"text-align:center;vertical-align:middle\">65<\/td><\/tr><tr><td style=\"text-align:center;vertical-align:middle\">50<\/td><td style=\"text-align:center;vertical-align:middle\">10<\/td><td style=\"text-align:center;vertical-align:middle\">30<\/td><\/tr><tr><td style=\"text-align:center;vertical-align:middle\">55<\/td><td style=\"text-align:center;vertical-align:middle\">9<\/td><td style=\"text-align:center;vertical-align:middle\">20<\/td><\/tr><tr><td style=\"text-align:center;vertical-align:middle\">60<\/td><td style=\"text-align:center;vertical-align:middle\">7<\/td><td style=\"text-align:center;vertical-align:middle\">15<\/td><\/tr><\/tbody><\/table><\/figure>\n\n\n\n<h3 class=\"wp-block-heading\">Product Line-up (APACERAM)<\/h3>\n\n\n\n<p>A variety of porosity and shapes are available depending on the intended use and implantation site, including versatile blocks, granules and various spacers.<\/p>\n\n\n\n<p>*Please refer to the catalog for details. (Please refer to the product catalog page)<\/p>\n\n\n<div class=\"wp-block-image\">\n<figure class=\"aligncenter size-full is-resized\"><img loading=\"lazy\" decoding=\"async\" width=\"557\" height=\"86\" src=\"https:\/\/www.hoyatechnosurgical.co.jp\/wp\/wp-content\/uploads\/2024\/09\/apaseram_lineup.jpg\" alt=\"\" class=\"wp-image-4979\" style=\"width:831px;height:auto\"\/><\/figure>\n<\/div>\n\n\n<p><\/p>\n\n\n\n<h2 class=\"wp-block-heading\">Features of APACERAM-AX<\/h2>\n\n\n\n<h3 class=\"wp-block-heading\">Triple pore structure<\/h3>\n\n\n\n<p class=\"has-text-align-center\">This is an ultra-high-porosity hydroxyapatite artificial bone with 85% porosity and a triple-pore structure:\u2460 Spherical macro pores, \u2461 Considerable interconnecting pores, \u2462 micro pores among the spherical particles<\/p>\n\n\n<div class=\"wp-block-image\">\n<figure class=\"aligncenter size-full is-resized\"><img loading=\"lazy\" decoding=\"async\" width=\"538\" height=\"264\" src=\"https:\/\/www.hoyatechnosurgical.co.jp\/wp\/wp-content\/uploads\/2024\/09\/apaseram-ax_photo1.jpg\" alt=\"\" class=\"wp-image-4991\" style=\"width:602px;height:auto\"\/><\/figure>\n<\/div>\n\n\n<h3 class=\"wp-block-heading\">Assimilation with bone tissue*<\/h3>\n\n\n\n<p>It bonds with the surrounding bone as new bone grows inside its pores.<\/p>\n\n\n\n<p>Implanted in the defect \u00d84mm \u00d7 6mmL in the iliac of the beagle (radiography).<\/p>\n\n\n<div class=\"wp-block-image\">\n<figure class=\"aligncenter size-full is-resized\"><img loading=\"lazy\" decoding=\"async\" width=\"538\" height=\"264\" src=\"https:\/\/www.hoyatechnosurgical.co.jp\/wp\/wp-content\/uploads\/2024\/09\/apaseram-ax_photo2.jpg\" alt=\"\" class=\"wp-image-4995\" style=\"width:506px;height:auto\"\/><\/figure>\n<\/div>\n\n\n<p class=\"has-text-align-center\">In 26th weeks after implantation, boundaries around the material became vague showing progress of new bone formation.<br>* To become almost same situation as bone tissue in terms of structures and functions.<\/p>\n\n\n\n<h3 class=\"wp-block-heading\">Early osteogenic ability<\/h3>\n\n\n\n<p>Interconnecting pore structure and porous inner wall structure of the pores enable early bone formation.<br>a) Implanted in the defect \u00d84mm \u00d7 6mmL in the iliac of the beagle (Toluidine blue staining).<\/p>\n\n\n<div class=\"wp-block-image\">\n<figure class=\"aligncenter size-full is-resized\"><img loading=\"lazy\" decoding=\"async\" width=\"538\" height=\"213\" src=\"https:\/\/www.hoyatechnosurgical.co.jp\/wp\/wp-content\/uploads\/2024\/09\/apaseram-ax_photo3.jpg\" alt=\"\" class=\"wp-image-4997\" style=\"width:604px;height:auto\"\/><\/figure>\n<\/div>\n\n\n<p class=\"has-text-align-center\">In 4 weeks after implantation, new bone formation was observed all over the implanted site with active new bone in the pores.<\/p>\n\n\n\n<p class=\"has-text-align-center\">b) Implantation of APACERAM-AX in the defect \u00d84mm \u00d7 12mmL in the iliac of the beagle. (Hematoxylin Eosin staining)<\/p>\n\n\n<div class=\"wp-block-image\">\n<figure class=\"aligncenter size-full is-resized\"><img loading=\"lazy\" decoding=\"async\" width=\"538\" height=\"271\" src=\"https:\/\/www.hoyatechnosurgical.co.jp\/wp\/wp-content\/uploads\/2024\/09\/apaseram-ax_photo4.jpg\" alt=\"\" class=\"wp-image-4999\" style=\"width:530px;height:auto\"\/><\/figure>\n<\/div>\n\n\n<p>In 4 weeks after implantation, new bone formation was observed in the pores and osteoblasts were found on the surface of the newly formed bone.<\/p>\n\n\n\n<h3 class=\"wp-block-heading\">Product Line-up (APACERAM-AX)<\/h3>\n\n\n\n<p><\/p>\n\n\n<div class=\"wp-block-image\">\n<figure class=\"aligncenter size-full is-resized\"><img loading=\"lazy\" decoding=\"async\" width=\"624\" height=\"373\" src=\"https:\/\/www.hoyatechnosurgical.co.jp\/wp\/wp-content\/uploads\/2024\/09\/apaseram-ax_photo5.png\" alt=\"\" class=\"wp-image-5001\" style=\"width:564px;height:auto\"\/><\/figure>\n<\/div>\n\n\n<figure class=\"wp-block-flexible-table-block-table is-content-justification-center\"><table class=\"has-fixed-layout\" style=\"width:100%\"><tbody><tr><td style=\"background-color:#2c66b0;color:#ffffff;text-align:center;vertical-align:middle;width:15%\">Product number<\/td><td style=\"background-color:#2c66b0;color:#ffffff;text-align:center;vertical-align:middle\">name<\/td><td style=\"background-color:#2c66b0;color:#ffffff;vertical-align:middle;text-align:center\">classification, name, abbreviated<\/td><td style=\"background-color:#2c66b0;color:#ffffff;text-align:center;vertical-align:middle\">packaging unit\/box<\/td><\/tr><tr><td style=\"text-align:center;vertical-align:middle;background-color:#2c66b0;color:#ffffff;width:15%\">GA-2<\/td><td style=\"text-align:center;vertical-align:middle\">Granules 1.0-2.0mm<\/td><td style=\"vertical-align:middle;text-align:center\">Artificial Bone, AB-01<\/td><td style=\"text-align:center\">2g<\/td><\/tr><tr><td style=\"text-align:center;vertical-align:middle;background-color:#2c66b0;color:#ffffff;width:15%\">GA-3<\/td><td style=\"text-align:center;vertical-align:middle\">Filler 3.0\u00b11.0mm<\/td><td style=\"vertical-align:middle;text-align:center\">Artificial Bone AB-01<\/td><td style=\"text-align:center\">2g<\/td><\/tr><tr><td style=\"text-align:center;vertical-align:middle;background-color:#2c66b0;color:#ffffff;width:15%\">A-1<\/td><td style=\"text-align:center;vertical-align:middle\">block 10\u00d710\u00d710mm<\/td><td style=\"vertical-align:middle;text-align:center\">artificial bone, AB-02<\/td><td style=\"text-align:center\">1ml\u00d71 Piece<\/td><\/tr><tr><td style=\"text-align:center;vertical-align:middle;background-color:#2c66b0;color:#ffffff;width:15%\">A-2<\/td><td style=\"text-align:center;vertical-align:middle\">block 10\u00d710\u00d720mm<\/td><td style=\"vertical-align:middle;text-align:center\">artificial bone, AB-02<\/td><td style=\"text-align:center\">2ml\u00d71 Piece<\/td><\/tr><tr><td style=\"text-align:center;vertical-align:middle;background-color:#2c66b0;color:#ffffff;width:15%\">A-3<\/td><td style=\"text-align:center;vertical-align:middle\">PLF Stick 4\u00d74\u00d740mm<\/td><td style=\"vertical-align:middle;text-align:center\">Artificial Bone \/ AB-13<\/td><td style=\"text-align:center\">1<\/td><\/tr><\/tbody><\/table><\/figure>\n\n\n\n<p><\/p>\n\n\n\n<p><\/p>\n","protected":false},"excerpt":{"rendered":"<p>APACERAM \/ APACERAM-AX Hydroxyapatite [Ca10(PO4)6(OH)2] has excellent biocompatibility and biological safety, and is available in a wide variety of APACERAM and ultra-high porosity APACERAM-AX with a porosity of 85% with a triple pore structure. APACERAM Biocompatible ceramic bone graft substitute APACERAM was created by our own unique technology. Approved products, models and indications may differ from country to country.Please contact us for detail. APACERAM-AX APACERAM-AX is a bone replacement material with a characteristic microstructure originally developed by our company, and means &#8220;new axial attachment (AXIS), highest (MAX) porosity, and highest (MAX) osteogenic capacity&#8221; in the APACERAM product group. Features of APACERAM Biocompatibility APACERAM consists of synthetic hydroxyapatite \u3014Ca10(PO4)6(OH)2\u3015that is an [&hellip;]<\/p>\n","protected":false},"author":1,"featured_media":6986,"comment_status":"closed","ping_status":"closed","template":"","format":"standard","meta":{"_acf_changed":false,"_coblocks_attr":"","_coblocks_dimensions":"","_coblocks_responsive_height":"","_coblocks_accordion_ie_support":"","footnotes":""},"category_medical_products":[77],"feature_medical_products":[78],"part_medical_products":[79],"class_list":["post-2984","medical_products","type-medical_products","status-publish","format-standard","has-post-thumbnail","hentry","category_medical_products-bone","feature_medical_products-non-absorbable-en","part_medical_products-non-dental-whole-body"],"acf":[],"yoast_head":"<!-- This site is optimized with the Yoast SEO plugin v27.4 - https:\/\/yoast.com\/product\/yoast-seo-wordpress\/ -->\n<title>Product information | Apaseram \/ Apaseram-AX<\/title>\n<meta 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