Product Information｜HOYA Technosurgical Corporation

“SUPERPORE” was developed by applying “Triple pore structure” of APACERAM Type-AX to absorbable tricalcium phosphate ceramics.
Clinical studies has shown excellent bone regeneration and balanced absorption of SUPERPORE and bone tissue replacement.
Three types of products with various porosity (75 – 57%) and strength (compressive strength: 5-48 MPa) are available depending on applying position and intended use. Blocks and granules are available for each type.

Approved products, models and indications may differ from country to country.
Please contact us for detail.

Features of SUPERPORE

1.　Triple pore structure developed using our unique technologies.

SUPERPORE promotes early bone regeneration and remedy of bone tissue into its pores.

2.　Well-balanced absorption of the material and replacement to bone

SUPERPORE makes the most of the property of high purity β-tricalcium phosphate to be replaced to autologous bone.

3.　Good operability in surgery

Uniform macro pore structure of approximately 200μm prevents breakage of the material.

Main specification

Generic name	β-tricalcium phosphate
Composition	Ca₃(PO₄)₂
Appearance	White porous material

1. High porosity type （porosity 75％)

High porosity type shows excellent bone absorbability of the material and bone replacement with high porosity (75%)

Triple Pore Structure

SUPERPORE has triple pore structure that is suitable for bone regeneration as illustrated in APACERAM Type-AX.

Surface structure (SEM images)
Macro pores: 100～300μm,　
Interconnecting pores: 50～100μm,　
Micro pores: 0.5～10μm

Fast bone formation, absorption and bone replacement

Evaluation by short to long term implantation test in canines.※3

Cortical bone：: New bone formation and absorption of material were observed in 4 weeks after implantation. Maturation of the new bone was observed in 8 weeks. Further maturation progressed in 13 weeks and the material was almost absorbed in 26 weeks.
Medullary cavity：: In 4 weeks after implantation, new bone formation and expansion of the pores were observed. Absorption of the material progressed in 8 weeks and bone marrow tissue was clearly observed in 13 weeks. The material was almost completely absorbed in 26 weeks.

As a result, regeneration of the bone was achieved in both cortical bone and medullary cavity including anatomical shape.

SUPERPORE high porosity type blocks (porosity 75%, Ø4mm x 12mmL) were implanted in the femurs of the canines and extracted in 4, 8, 13 and 26 weeks. Samples stained by toluidine blue were prepared for observation. (Implantation test was executed in accordance to ISO10993 in the facility of GLP level.)

Product Line-up

Granules, blocks, and cylinder models are available.

2. Balanced type (Porosity 67%)

Balance type has characteristics with boneabsorption of the material and bone replacement due to its high porosity (67%) consisting moderate strength (compressive strength: 20MPa).

Triple Pore Structure

Fast bone formation, absorption and bone replacement

SUPERPORE balanced type blocks (porosity 67%, Ø4mm x 12mmL) were implanted in the femurs of canines and extracted in 4 and 13 weeks. Samples stained by toluidine blue were prepared for observation. Implantation tests were executed in accordance to ISO10993 in the facility of GLP level.

Active bone formation was observed around the material in 4 weeks. Early stage of the bone formation was observed in the pores whileabsorption of the SUPERPORE (Balanced type) l and replacement of new bone tissues were observed immediately below the periosteum and at the interface of the medullary cavity.
In 13 weeks, bone formation continuing the host bone and absorption of the material were observed in the cortical area, while medullary cavity and adipose tissues were formed in the medullary cavity area.

Product Line-up

Granules, blocks, cylinder and wedge models are available.

3. High Strength type（porosity 57％）

High strength type is characterized by high mechanical strength (compressive strength: 48MPa) and triple pore structure that is suitable for fast bone formation.

Triple pore structure suitable for bone regeneration (porosity 57%)

【Structure】	【Form】
Triple pore structure	Macro pores	40〜200μm
	Interconnecting pores	≥40μm
	Micro pores	≤10μm

Well balanced bone formation and absorption of the material, regeneration of the bone tissue and fast bone formation

SUPERPORE high strength type blocks (porosity 57%, Ø4mm x 12mmL) were implanted in the femurs of the beagles and extracted in 26 and 52 weeks. Undecalcified samples stained by Hematoxylin and Eosin were prepared for observation. Implantation test was executed in accordance to ISO10993 in the facility of GLP level.

26 weeks after implantation：Bone formation continuing to host bone and absorption of the material and replacement by bone were observed in the cortical area. 52 weeks after implantation: The material was almost absorbed and replaced by bone. Bone regeneration was observed allover the implantation area including anatomical form.

Product Line-up

Granules, blocks, cylinder and wedge models are available.